Tonight I grilled some bison burgers for supper. If you've never eaten bison, you're missing out.
Bison has a flavor signature that differs from beef, in that it has just a hint of sweetness. I also think it's a slightly heavier taste than traditional beef. I have no scientific proof, but my gut tells me that since bison has much less fat and grease than a hamburger, you taste more of the actual meat.
If you try some, please don't over cook it. Since it has less fat than hamburger, you don't need to cook it as much.